Minoxidil / Finasteride / Tretinoin Solution


Minoxidil / Finasteride / Tretinoin Solution is a combination of drug products that have been formulated into a topical solution to address androgenetic alopecia (the most common type of hair loss, driven by genetics and hormonal changes). The active ingredients in this preparation work synergistically to counteract the effects of testosterone metabolism and allow the hair to regrow. The preparation is applied to the affected area once daily and may take up to four months of therapy to see a response.


What was once used as an oral medication to treat high blood pressure, minoxidil applied topically is widely used today to stimulate the regrowth of hair without systemic vasodilation effects.1 Its mechanism of action is unknown with regards to hair regrowth, but research suggests it decreases the latent period of the hair cycle (the time between shedding of telogen (resting) hair and the start of the next growth phase).2, 3 In other words, topical minoxidil may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen (growth) phase.

Topical minoxidil is generally well tolerated and can be effective by itself if used during the early onset of alopecia. It is likely successful in promoting moderate hair growth in approximately 30% of men and 60% of women with androgenetic hair loss.4 Minoxidil is also known to stop the worsening of alopecia or provide mild hair growth.5 


In normal testosterone metabolism, the body uses the enzyme 5-alpha reductase to convert it into dihydrotestosterone (DHT). Long-term exposure to DHT has been shown to shrink and damage hair follicles. Since 5-Alpha reductase is found in the oil glands of hair follicles, it is believed that this pathway is a potential culprit in the progression of androgenetic alopecia. Researchers have found that by suppressing the production of DHT, hair follicle miniaturization can be slowed down or stopped if caught early enough.6, 7

Finasteride is a powerful 5-alpha reductase inhibitor found in this formulation. It was originally approved by the FDA to increase and maintain maximum urine flow rate in men suffering from benign prostatic hyperplasia (BPH), a common condition in men over 50.8 It was later approved as an oral treatment for mild to moderate male pattern baldness of the vertex and anterior mid-scalp area in men.9 Researchers have found that combining topical finasteride with topical minoxidil may produce better results as compared to topical minoxidil alone.10 Common side effects of taking oral forms of finasteride include low libido, erectile dysfunction, reduced ejaculatory volume, and gynecomastia.11, 12  Fortunately, it has been studied that topical finasteride, has a much lower systemic absorption than oral formulations and may not induce these adverse effects while still providing similar therapeutic outcomes as oral formulations.10, 11, 12


Vitamin A has been shown to play a role in the differentiation, growth and regulation of the human hair cycle.13 These features make tretinoin, a derivative of vitamin A, an attractive candidate for addressing hair loss. While scientific evidence is still lacking from large studies to prove these effects, tretinoin has been studied in combination with minoxidil for treating male pattern baldness (androgenetic alopecia). After one year of the topically applied treatment, an increase in hair growth was reported in 58% of patients.14 It’s important to note that excessive retinoid levels have been implicated in the pathogenesis of various hair disorders.13 As such, oral retinoids and highly concentrated topical retinoids are not recommended for treating androgenetic alopecia.


Minoxidil is indicated for the use of androgenetic alopecia.13 Finasteride is indicated for the use of BPH and male pattern hair loss in men.9

How Supplied

Minoxidil is widely available over-the-counter and formulated as a topical solution or foam to help regrow hair. Finasteride is available commercially as an oral tablet to treat BPH or androgenetic alopecia.

Several over-the-counter topical products contain 2% or 5% minoxidil, however patients that would benefit from the addition of finasteride and tretinoin may be prescribed this compounded preparation as determined by a prescriber. The most popular formulation compounded at Galleria Medical Pharmacy is Minoxidil 5% / Finasteride 0.1% / Tretinoin 0.025% Solution, though other strengths and formulations may be available upon request.


Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.


  1. Elise A.OlsenM.D.,Madeline S.WeinerR.N., B.S.N. Topical minoxidil in male pattern baldness: Effects of discontinuation of treatment. Journal of the American Academy of Dermatology Volume 17, Issue 1, July 1987, Pages 97-101.
  2. Buhl AE. Minoxidil’s action in hair follicles. J Invest Dermatol 1991;96:73S-4S.
  3. Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol 2004;150:186-194.
  4. DeVillez RL. The Therapeutic Use of Topical Minoxidil. Dermatol Clin 1990;8:367-74.
  5. Olsen EA, Dunlap FE, Funicella T, et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 2002;47:377-85.
  6. Jang S1, Lee Y, Hwang SL, Lee MH, Park SJ, Lee IH, Kang S, Roh SS, Seo YJ, Park JK, Lee JH, Kim CD. Establishment of type II 5alpha-reductase over-expressing cell line as an inhibitor screening model. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):245-52. Epub 2007 Jun 22.
  7. Ustuner, Emin Tuncay. “Cause of Androgenic Alopecia: Crux of the Matter.” Plastic and Reconstructive Surgery Global Open 1.7 (2013): e64. PMC. Web. 3 Oct. 2017.
  8. Proscar (finasteride) package insert. Whitehouse Station, NJ: Merck and Co.; 2014 Jan.
  9. Propecia (finasteride) package insert. Whitehouse Station, NJ: Merck and Co.; 2010 Dec.
  10. Tanglertsampan, Chuchai. J Med Assoc Thai. Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in male pattern hair loss: a randomized, double-blind, comparative study. 2012 Oct;95(10):1312-6.
  11. Caserini M, et al. A novel finasteride 0.25% topical solution for androgenetic alopecia: Pharmacokinetics and effects on plasma androgen levels in healthy male volunteers. International Journal of Clinical Pharmacology and Therapeutics. 2014 Jul;52(10).
  12. Hajheydari Z, Akbari J, Saeedi M, Shokoohi L. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol 2009;75:47-51.
  13. Helen B Everts. Endogenous retinoids in the hair follicle and sebaceous gland. Biochim Biophys Acta. 2012 Jan;182(1):222-229.
  14. Bazzano GS, et al. Topical tretinoin for hair growth promotion. J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):880-3, 890-3.
  15. Rogaine 5% foam package insert. Morris Plains, NJ: Pfizer Consumer Healthcare; 2006 Jan.

Compounding Pharmacy Statement

This preparation is compounded with drug components whose suppliers are registered with the FDA. While Galleria Medical Pharmacy adheres to USP <795> guidelines and applicable state and federal regulations to meet the required quality standards, the statements made regarding this preparation have not been evaluated by the FDA for safety or clinical effectiveness. As such, this preparation is not intended to diagnose, treat, cure, or prevent any disease. For inquiries concerning this preparation, please contact (504) 267-9876.