Tranexamic Acid Cream

Overview

Exposure to UV radiation from the sun is the main trigger for melasma. Tranexamic acid when applied topically has been found to interrupt the process that causes melasma. It works by inhibiting plasminogen activation to help prevent UV-induced melasma flare-ups from happening in the first place.

Tranexamic acid is used traditionally in hospitals and dentistry for controlling blood loss. Since its systemic administration can increase the risk of thromboembolic events, tranexamic acid is contraindicated in patients with active thromboembolic disease or those with a history or intrinsic risk of thrombosis or thromboembolism. Topical administration of tranexamic acid is associated with less side effects since it is not systemically absorbed. Additionally, there may be less significant side effects from using tranexamic acid cream as compared to those containing hydroquinone. Hydroquinone is effective at reducing hyperpigmentation, however there is more inflammation associated with its use than with the use of tranexamic acid.^{1, 2}